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Anesthesiology Clinical Research Center
The Anesthesiology Clinical Research Center (ACRC) conducts clinical research with federal, foundation, and industry funding. The Department of Anesthesiology Research Committee (Drs. Eaton as Chair, Bailey, Dworkin, Glance, Papadakos, Thakur and Zollo) oversees the activities of the ACRC. Janet Vaughan, MS, NP, serves as the operations director of the center, and oversees a staff of three other nurses and one secretary. The ACRC has all the equipment and resources necessary for the performance of inpatient and outpatient clinical trials according to Good Clinical Practice, and also has the instruments (e.g., Medoc TSA-II Neurosensory Analyzer) and experience necessary to perform quantitative sensory testing using thermal, electrical, tactile, and vibratory stimuli.
One of the major areas of ACRC research has been Phase II, III, and IV clinical trials of treatments for outpatients with a wide variety of chronic pain conditions. The ACRC has particular expertise in clinical trials of the treatment and prevention of neuropathic pain, especially postherpetic neuralgia and painful diabetic neuropathy. It has been a very active center for multicenter clinical trials conducted by industry sponsors for the development of new analgesic drugs and in evaluating analgesic indications for existing medications.
Studies of inpatients have also been conducted for many years by the staff of the ACRC, including research on ARDS and post-operative pain. Faculty members who have conducted these ACRC studies have played major roles in multicenter ICU clinical trials and are nationally recognized for these contributions.
In addition, the ACRC has been very involved in serving as the coordinating center for the Shingles Trial of Oral Medications to Prevent Postherpetic Neuralgia (STOMP-PHN) Pilot Study. This study is currently enrolling study subjects at the Universities of Alabama, Rochester, and Texas, and is providing data in support of a future NIH grant for a full multicenter clinical trial.
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| Principal Investigator | Title | Sponsor | Start | End | Total |
| SPONSORED RESEARCH |
| Brookes, Paul S. |
Mitochondria & NO in Cardiac Ischemia-Reperfusion |
DHHS /PHS /NIH |
08/01/03 |
07/31/07 |
$1,260,000 |
| Dworkin, Robert H. |
Analgesia in Herpes Zoster and Postherpetic Neuralgia |
DHHS /PHS /NIH |
09/01/01 |
08/31/04 |
$239,250 |
| Dworkin, Robert H. |
Post-Mastectomy and Phantom Breast Pain: Risk Factors, Natural History, and Impact on Quality of Life |
DOD /ARMY /AMRDC |
07/01/98 |
01/31/03 |
$306,343 |
| Glance, Laurent G. |
Are Volume Standards Accurate Measures of Quality? |
DHHS /PHS /AHRQ |
09/30/03 |
09/29/06 |
$888,738 |
| Karan, Suzanne Beth |
Validation of a Method to Predict Sedation Induced Upper Airway Obstruction |
Fnd for Anesthesia Ed Res |
07/01/04 |
06/30/06 |
$84,927 |
| Ward, Denham |
Role of the Peripheral Chemoreceptors in the Counter-Regulatory Response to Hypoglycemia and Hypoxia |
American Diabetes Association |
01/01/04 |
12/31/06 |
$294,408 |
| Yoon, Yisang |
Regulation of Mitochondrial Morphology in Liver Cells |
DHHS /PHS /NIH |
09/01/03 |
06/30/08 |
$1,212,752 |
| Eaton, Michael |
A Multicenter, Open-Label, Phase IIIa trial to evaluate the Safety and Efficacy of Org 15969 When Used at the End of Surgical Procedure to Reverse the Neuromuscular Block Induced by Rocuronium following Routine Anesthesia. |
Organon Pharmaceuticals |
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$35,000 |
| Eaton, Michael |
Evaluation of Clevidipine in Perioperative Treatment of Hypertension Assessing Safety Events with Sodium Nitroprusside as Active Comparitor |
The Medicines Company |
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$145,000 |
| Eaton, Michael |
Evaluation of Clevidipine in Postoperative Treatment of Hypertension Assessing Safety Events with Nicardipine as Active Comparitor. |
The Medicines Company |
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$145,000 |
| Zollo, Raymond |
Using Standardized Patients to Investigate Patient Centered Preoperative Communication |
Fnd for Anesthesia Ed Res |
01/01/04 |
12/31/05 |
$25,000 |
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| Principal Investigator |
Title |
Sponsor |
Start |
End |
Total |
| INSTRUCTION/TRAINING GRANTS |
| Stern, David H. |
Team Crisis Training in the Surgical Suite |
MCIC Vermont, Inc. |
08/01/98 |
06/30/02 |
$45,910 |
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| Principal Investigator |
Title |
Sponsor |
Start |
End |
Total |
| CLINICAL RESEARCH/ CLINICAL TRIALS |
| Dworkin, Robert H. |
Assessment of Safety and Tolerability of Oral Sustained Release Tramadol vs. Oral Immediate Release Tramadol in Pts with Chronic Non-Malignant Pain
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ASTA Medica |
03/23/99 |
06/30/03 |
$73,334 |
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